Ivanovic's injury means Ashley Cole is set to return at left-back with Cesar Azpilicueta switching to the right, while midfielder Ramires is back from a one-game ban.
For Southampton, Dani Osvaldo suffered a knock in the 1-1 draw at Newcastle and, having recovered from that, was then struck down by illness, but could return for the match against the Blues.
Morgan Schneiderlin returns from suspension while Nathaniel Clyne will be hoping to start as he steps up his return from a hamstring complaint.
Artur Boruc (hand), Victor Wanyama (shin) and Guly do Prado (knee) remain sidelined.
Chelsea's provisional squad: Cech, Cole, Essien, Ramires, Torres, Mata, Oscar, Mikel, Schurrle, De Bruyne, Hazard, Ba, Willian, Schwarzer, Cahill, Terry, Azpilicueta, Eto'o, Blackman, Bertrand.
Southampton's provisional squad: K Davis, Gazzaniga, Cropper, Clyne, Chambers, Shaw, Fox, Lovren, Fonte, Yoshida, Hooiveld, Schneiderlin, Reed, Cork, S Davis, Ward-Prowse, Ramirez, Rodriguez, Lallana, Gallagher, Osvaldo, Lambert.