Heart-throb Depp's latest film The Lone Ranger, in which he plays Native American sidekick warrior Tonto, got panned by some critics.
And yesterday he admitted life as an actor is "a kind of insane option for a human being".
The 50-year-old star said he would not be "dropping out any second" but the moment was "probably not too far away".
He told BBC Breakfast: "At a certain point you start thinking and you know when you add up the amount of dialogue you say per year, for example, and you realise that you've said written words more than you've actually had a chance to say your own words, you start thinking about that as a kind of insane option for a human being.
"So are there quieter things that I wouldn't mind doing? Yeah, I would not mind that."